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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 48-year-old African American woman presents with BP = 142/96 mm Hg. Serum chemistry values are all within normal ranges. Lifestyle modification was initiated 6 months ago when BP was 146/94 mm Hg. The pharmacotherapy specialist should recommend which of the following?

A) Atenolol 25 mg daily
B) Hydrochlorothiazide 12.5 mg daily
C) Continued lifestyle modification
D) Losartan 25 mg daily

2. Investigators studying the relative nephrotoxicity of two aminoglycosides selected their sample size to detect a reduction in toxicity of 10%. Which of the following is the power of this study if the probability of falsely rejecting the null hypothesis is 0.05 and the probability of falsely accepting the null hypothesis is 0.20?

A) 0.95
B) 0.80
C) 0.05
D) 0.10

3. A study compared treatment with cinacalcet versus treatment with placebo in subjects with known hyperparathyroidism. The primary outcome of the study was the proportion of study subjects with a mean intact parathyroid hormone level < 250 pg/mL. Among the cinacalcet group (n = 371), 43% of subjects achieved the primary outcome; among the placebo group (n =
370), 5% achieved the primary outcome (p<0.05).
Which of the following is the number needed to treat (NNT)?

A) 1
B) 14
C) 8
D) 3

4. A 70-year-old 45-kg patient is admitted to the ICU with a diagnosis of digoxin intoxication. The patient complains of nausea, blurred vision, and fatigue that have been present for 3 days. A cardiac monitor reveals a HR of 42 bpm, an irregular rhythm, and a type second-degree heart block. Current medications include digoxin 0.25 mg and furosemide 40mg for heart failure, both taken daily at 0800. The patient remains adherent to all medications despite nausea, including today's doses. Blood is drawn at 1200 with the following results:
* Potassium: 6.0 mEq/L
* Creatinine: 2.3 mg/dL
* Digoxin: 1.7 ng/mL
Which of the following most appropriately describes the patient's digoxin concentration?

A) A concentration within the desirable range
B) Reflects the effect of furosemide on the renal excretion of digoxin
C) A pre-distribution digoxin concentration, which may be misinterpreted
D) A post-distribution digoxin concentration, which indicates significant toxicity

5. A 35-year-old patient presents with symptoms consistent with acute pharyngitis. The patient reports no other illnesses, no known drug allergies, and a medical history significant for generalized anxiety disorder. The appropriate therapy should be determined by testing for which of the following?

A) Haemophilus influenzae
B) Streptococcus pneumoniae
C) Group A Streptococcus
D) Staphylococcus aureus

Solutions: